Metitepine mesylate salt

Name	METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT
Synonyms	Ro 8-6837 mesylate Metitepine mesylate salt methiothepin mesylate salt METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt 1-Methyl-4-(8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine methanesulfonate Methiothepin mesylate 1-Methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine Metitepine mesylate salt, 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt
CAS	74611-28-2

Molecular Formula	C20H24N2S2CH3SO3H
Molar Mass	452.65
Solubility	H2O: soluble13mg/mL
Appearance	solid
Color	white
Storage Condition	Room Temprature
In vitro study	Methiothepin mesylate is a 5-HT receptor antagonist, with pK d s of 7.10, 7.28, 7.56, and 6.99 for 5-HT 1A , 5HT 1B , 5HT 1C , 5HT 1D . Methiothepin mesylate also shows pK d s of 7.0, 7.8, 8.74, and 8.99 for 5-HT 5A , 5-HT 5B , 5-HT 6 , and 5-HT 7 , respectively. Methiothepin exhibits high affinity at 5-HT 2A , 5HT 2B , and 5HT 2C with pK i s of 8.50, 8.68, and 8.35, respectively.